Figure: Cobalamin transport, into enterocytes (Mouse)¶
The diagram illustrates the pathway of cobalamin (vitamin B12) transport into mouse enterocytes. The process begins in the extracellular space where cobalamin (B12) is bound to transcobalamin II (Tcn2). Proteases (Prss1, Ctrb1, Prss3) process this complex, allowing B12 to be bound by Cblif (intrinsic factor). The Cblif-B12 complex is then recognized by the receptor complex Cubn-Amn1 located in the microvillus membrane of enterocytes. Following receptor binding, the complex undergoes endocytosis. In the cell, Lmbrd1 facilitates the export of B12 from lysosomes, and finally, Abcd4 transports B12 to the endoplasmic reticulum, completing the cellular uptake process.
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{"feedback":"The diagram effectively illustrates the cobalamin transport pathway in mouse enterocytes, clearly showing the progression from the extracellular space through the microvillus membrane and into various cellular compartments. The use of distinct colors for different protein types (carriers, proteases, receptors) enhances understanding of their functional roles. The addition of process labels helps clarify the biological mechanisms involved at each step. The expanded legend provides important context about the overall pathway and key components, making this suitable for publication in a high-impact journal like Cell or Nature.","necessary_changes":null,"optional_changes":null}