Figure: Poxvirus-OPG044 inhibition of interferon beta induction (Human-Poxvirus)¶
This diagram illustrates the mechanism by which Poxvirus protein VACWR039 (P68466) inhibits the type I interferon production pathway in human cells. The viral protein sequesters DDX3X (O00571) in the cytoplasm, preventing it from acting as a signaling adaptor. This inhibition blocks the normal pathway where DDX3X would activate IKBKE (Q14164), which normally phosphorylates IRF3 (Q14653-5). When phosphorylated, IRF3 would translocate to the nucleus and function as a DNA-binding transcription activator to induce IFNB1 gene expression. The solid red line with inhibition symbol represents direct inhibition by the viral protein, while dashed gray lines represent the inhibited normal pathway steps.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the Poxvirus-OPG044 inhibition of interferon beta induction pathway. It clearly shows how the viral protein VACWR039 sequesters DDX3X in the cytoplasm, preventing the signaling cascade that would normally lead to interferon beta production. The cellular compartmentalization into cytoplasm and nucleus helps visualize the spatial aspects of the pathway, while the color coding distinguishes viral from host proteins. The addition of specific interaction labels on the arrows (sequestering, activates, phosphorylates, translocation) enhances understanding of the mechanisms involved in each step.","necessary_changes":null,"optional_changes":"To further improve this scientific figure, you could consider adding a small inset showing the entire cell in the context of viral infection, or include a simplified version of the active pathway (without viral inhibition) for comparison."}