Figure: Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus)¶
The diagram illustrates the molecular pathway of poxvirus inhibition of ZBP1-mediated necroptosis. VACWR059 (poxvirus protein) in the cytoplasm inhibits ZBP1's RNA binding ability (red inhibition line), which normally activates RIPK3 in the nucleus (dashed activation arrow). When activated, RIPK3 phosphorylates MLKL, which translocates to the plasma membrane to execute necroptosis through membrane disruption (purple wavy line). The colors represent human proteins (green/blue/purple) and viral proteins (red), with arrows indicating activation and inhibition relationships. This pathway demonstrates how poxviruses evade host immune responses by blocking cell death mechanisms.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the pathway of poxvirus inhibition of ZBP1-mediated necroptosis, with clear compartmentalization of cellular components (nucleus, cytoplasm, plasma membrane). The interactions between proteins are clearly depicted with appropriate arrows indicating activation and inhibition. The improved contrast between text and background, along with the thicker arrows, enhances readability and visual clarity. The addition of brief descriptions to each process label provides helpful context, and the comprehensive legend ensures viewers can easily interpret all elements of the diagram.","necessary_changes":null,"optional_changes":null}