Figure: Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus)¶
This figure illustrates the mechanism by which Poxvirus protein OPG025 (VACWR019) inhibits the human antiviral IFIT proteins. The pathway begins with IFNB1 (type I interferon) signaling from the extracellular space to induce expression of antiviral IFIT proteins (IFIT1, IFIT2, IFIT3) in the cytoplasm. These IFIT proteins normally function by binding viral RNA to suppress viral replication as part of the innate immune response. The poxvirus protein OPG025 acts as a molecular adaptor that enhances CUL1 (part of the SCF ubiquitin ligase complex) activity, promoting the degradation of IFIT proteins and ultimately leading to suppression of the host immune response.
Feedback from AI on figure:
{"feedback":"The final diagram effectively illustrates the Poxvirus-OPG025 inhibition pathway of antiviral IFITs in a clear and visually appealing manner. The figure uses appropriate shapes and colors to distinguish between different molecular components and their interactions. The spatial organization clearly shows the flow from extracellular signaling to intracellular processes, with the poxvirus intervention highlighted. All text is readable and properly contained within their respective elements, and the added background elements help distinguish between cellular compartments. The legend provides helpful context for interpreting the symbols used in the diagram.","necessary_changes":null,"optional_changes":null}