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Figure: Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus)

id: gomodel:62b4ffe300000906

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This figure illustrates the Poxvirus-OPG065 inhibition of the ISG15 conjugation pathway in human cells.

The pathway begins with UBA7 (ISG15 activating enzyme), which activates ISG15. The process continues with UBE2L6 (ISG15 transferase) and culminates with HERC5 (ISG15 transferase) conjugating ISG15 to target proteins.

The viral protein VACWR059 from poxvirus inhibits this process by sequestering ISG15, preventing it from functioning as a protein tag. This represents a viral mechanism to evade host immune defenses, as ISG15 conjugation is part of the innate immune response against viral infection.

All components shown are situated in the cytoplasm. Target proteins (shown with dashed lines) are implied and not explicitly mentioned in the source GO-CAM model.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the ISG15 conjugation pathway and how the poxvirus protein VACWR059 inhibits this process. The layout is clear, with each step labeled appropriately: 'ISG15 activation,' 'ISG15 transfer,' and 'ISG15 conjugation.' The involvement of UBA7, UBE2L6, and HERC5 is neatly organized in a sequential manner, making the pathway easy to follow. The negative regulation by VACWR059 is visually distinct, with a red inhibition symbol and arrows indicating the mechanism of inhibition, which enhances understanding. The color-coding of different pathway components and processes further improves visual clarity and comprehension.","necessary_changes":null,"optional_changes":null}