Figure: Ochratoxin A biosynthesis & catabolism (A. niger)¶
This diagram illustrates the Ochratoxin A biosynthesis and catabolism pathway in Aspergillus niger, styled as a scientific figure for publication.
The biosynthetic pathway (top) involves four enzymes: • OtaA (A2R6H1): Catalytic activity (GO:0003824) - Processes malonyl-CoA and acetyl-CoA • OtaC (A2R6G9): Oxidoreductase activity (GO:0016491) - Catalyzes oxidation-reduction reactions • OtaB (A2R6H0): Non-ribosomal peptide synthetase activity (GO:1904091) - Processes L-phenylalanine • OtaD (A2R6G7): Catalytic activity (GO:0003824) - Final step in ochratoxin A synthesis
The catabolic pathway (bottom) occurs in the extracellular region: • Am2 (A2R2V4): Carboxypeptidase activity (GO:0004180) - Degrades ochratoxin A to ochratoxin alpha
The dashed, curved line with vesicle representation indicates the implicit secretion of ochratoxin A from the cell to the extracellular region, which is not explicitly stated in the GO-CAM but necessary for the catabolic process to occur.
Feedback from AI on figure:
{"feedback":"The final diagram effectively illustrates the Ochratoxin A biosynthesis and catabolism pathway in Aspergillus niger in a format suitable for scientific publication. The illustration clearly distinguishes between the biosynthetic process inside the cell and the catabolic process in the extracellular region. The diagram features several strengths: clear labeling of enzymes with their UniProt identifiers and GO molecular function terms, distinct visual grouping of related reactions, proper pathway flow with directional arrows, visual distinction between biosynthetic and catabolic enzymes, improved representation of the secretion process, enhanced text readability, and a comprehensive legend explaining all visual elements. The diagram successfully balances scientific accuracy with visual clarity, making it appropriate for inclusion in publications like Cell or Nature.","necessary_changes":null,"optional_changes":null}