Figure: Ilicicolin H (Neonectria sp. strain DH2)¶
This diagram illustrates the biosynthetic pathway of ilicicolin H in Neonectria sp. strain DH2 based on the GO-CAM model. The pathway involves four key enzymes (IliA, IliB, IliC, and IliD) that catalyze sequential reactions transforming basic substrates into the final antifungal compound ilicicolin H.
Color coding in the diagram: - Blue boxes: Substrates (Acetyl-CoA, Malonyl-CoA, S-adenosyl-L-methionine, and L-tyrosine) - Green boxes: Enzymes (IliA, IliB, IliC, and IliD) with their molecular functions - Orange boxes: Reaction intermediates - Red oval: Final product (ilicicolin H)
The pathway begins with IliB (an enoyl-ACP reductase) which regulates IliA. IliA functions as both a non-ribosomal peptide synthase and polyketide synthase that combines the substrates to form the first intermediate. This intermediate is then modified by IliC (an oxidoreductase) and finally cyclized by IliD to produce ilicicolin H.
Feedback from AI on figure:
{"feedback":"This diagram effectively communicates the biosynthetic pathway of ilicicolin H in Neonectria sp. strain DH2 in a clear, visually appealing format suitable for a scientific journal. The pathway logic is easy to follow with well-defined components and directional flow.","necessary_changes":null,"optional_changes":"For future enhancements, including simplified chemical structures of the intermediates could provide additional context for biochemists, though this would increase diagram complexity."}