Figure: Poxvirus-OPG043 inhibition of host PKR (Human-Poxvirus)¶
The diagram illustrates the Poxvirus-OPG043 (VACWR034) inhibition of host PKR pathway in a human cell's cytoplasm. Color coding: green (viral protein), red (host immune protein), and blue (translation factors). The diagram shows how the viral protein VACWR034 (P18378) inhibits the host PKR/EIF2AK2 (P19525), which normally inhibits EIF2A (Q9BY44). EIF2A activates EIF2S2 (P20042), and both are translation initiation factors involved in translational initiation (GO:0006413). This cascade represents the viral strategy to suppress the host's antiviral immune response (GO:0140374) by interfering with PKR signaling (GO:0039580). Arrows indicate inhibitory (red) or activating (green) relationships between proteins.
Feedback from AI on figure:
{"feedback":"This diagram provides a clear and visually appealing representation of the Poxvirus-OPG043 inhibition of host PKR pathway. The illustration effectively uses color coding to distinguish between viral proteins, host immune proteins, and translation factors, making the pathway components easily identifiable. The increased font sizes improve readability throughout the diagram, and the addition of a comprehensive legend helps viewers understand the significance of different elements. The pathway context annotation adds valuable information about the biological significance of this interaction. The diagram successfully captures the essence of the GO-CAM model, showing how the viral protein VACWR034 disrupts the host's antiviral immune response by inhibiting PKR, which normally regulates translation initiation through EIF2A and EIF2S2. The cellular compartmentalization (cytoplasm) is clearly indicated, and all relevant GO terms are appropriately labeled.","necessary_changes":null,"optional_changes":null}