Figure: Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus)¶
Legend: • Shapes: - Circle: Viral protein (VACWR022) - Rectangle with rounded corners: Host proteins (TANK, TBK1, IRF3) - Rectangle: Gene (IFNB1) - Oval: Nucleus - Rounded rectangle: Cell membrane, Viral compartment, Process annotations
• Colors: - Pink (#ff9999): Viral protein - Light blue (#99ccff): Host proteins - Light green (#ccffcc): Gene - Light yellow (#ffffcc): Biological processes - Light blue (#e6f2ff): Nucleus - Light gray (#f8f9fa): Cell cytoplasm
• Arrows and Lines: - Red line with arrow: Inhibition - Solid black line with arrow: Activation - Dashed black line with arrow: Disrupted activation
• Text: - GO annotations provided with each component and interaction - Italics used for pathway annotations - "(not in source)" indicates element added for pathway clarity
Feedback from AI on figure:
{"feedback":"This SVG drawing effectively illustrates the Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK pathway as described in the GO-CAM model. The diagram clearly shows the spatial organization with distinct cellular compartments (cytoplasm and nucleus) and the key molecular interactions. The inhibitory action of the viral protein VACWR022 on TANK is well-represented with a red inhibitory arrow, and the downstream effects on TBK1 and IRF3 are logically arranged. The use of different shapes and colors for different molecule types enhances readability, and the GO terms are properly annotated to provide scientific context. The diagram maintains a good balance between simplicity and informative content, making it suitable for inclusion in a scientific journal.","necessary_changes":null,"optional_changes":null}