Figure: Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus)¶
This figure illustrates the poxvirus inhibition of the host type I interferon signaling pathway. Human JAK1 (P23458) in the cytoplasm performs protein tyrosine kinase activity that positively regulates STAT2's (P52630) DNA-binding transcription factor activity. Human HDAC4 (P56524) associated with chromatin performs molecular adaptor activity that also positively regulates STAT2. The poxvirus protein VACWR022 (P17362) enters the nucleus and performs protein sequestering activity that negatively regulates both STAT2's transcription factor activity and HDAC4's adaptor activity, thereby suppressing the host type I interferon-mediated signaling pathway.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the Poxvirus-OPG029 inhibition pathway as described in the GO-CAM model. The cellular compartments (cytoplasm and nucleus) are clearly delineated, and the key proteins (JAK1, HDAC4, STAT2, and VACWR022) are distinctly represented with appropriate shapes and colors. The molecular functions are indicated through text labels, and the regulatory relationships are shown with arrows and intuitive +/- symbols. The addition of a comprehensive legend enhances the clarity of the diagram, making it suitable for publication in a scientific journal.","necessary_changes":null,"optional_changes":null}