Figure: Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus)¶
This pathway diagram illustrates the Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling. The viral protein VACWR056 (P07396) enters the host cell and activates RICTOR (Q6R327) in the Golgi apparatus. RICTOR then activates AKT1 (P31749) in the cytoplasm, which in turn inhibits CGAS (Q8N884) in the cytosol. This inhibition disrupts the innate immune response by preventing cGAMP synthesis, allowing viral proliferation. Green arrows indicate activation (RO:0002629), while red arrows indicate inhibition (RO:0002630). TORC2 complex (shown with dashed lines) is implicit and not directly mentioned in the source data.
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively illustrates the Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling. The use of color-coded arrows clearly distinguishes between activation (green) and inhibition (red) interactions, making the pathway flow intuitive to follow. The subcellular compartments are well-defined with distinct colors and labels, providing important spatial context. Protein labels include both names and UniProt identifiers, enhancing scientific accuracy. The inclusion of molecular function descriptions in readable text boxes helps explain the biological activities at each step. The comprehensive legend explains the symbols used and provides context for understanding implicit elements not directly mentioned in the source data.","necessary_changes":null,"optional_changes":null}