Figure: Poxvirus-OPG193 interferon gamma decoy receptor (Human-Poxvirus)¶
This figure depicts the Poxvirus-OPG193 interferon gamma decoy receptor pathway. The Poxvirus protein P24770 (VACWR190) exhibits receptor decoy activity in the extracellular space, where it competitively inhibits interferon gamma (IFNG, P01579) and disrupts the normal interferon signaling. On the plasma membrane, the IFNG receptors IFNGR1 (P15260) and IFNGR2 (P38484) would normally bind IFNG to initiate the type III interferon signaling pathway (GO:0038196). JAK1/JAK2 proteins (marked with asterisk) are shown as implicit components not explicitly mentioned in the source GO-CAM model. Green arrows indicate activation pathways while red arrows show inhibitory interactions. This virus-mediated suppression of host innate immune response (GO:0052170) demonstrates a key mechanism by which poxviruses evade host defenses.
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively captures the Poxvirus-OPG193 interferon gamma decoy receptor system with accurate representation of the key components and their interactions. The visual distinction between extracellular space and the cell interior with the plasma membrane is clear and well-labeled. The diagram successfully illustrates how the viral protein P24770 (OPG193) functions as a decoy receptor to interfere with normal interferon gamma signaling by negatively regulating IFNG (P01579). The receptors IFNGR1 and IFNGR2 are properly positioned at the plasma membrane, and the downstream signaling pathway is indicated. The use of different shapes and colors helps distinguish between the various components, and the directional arrows clearly show the flow of signaling and inhibition. The legend is comprehensive and helps readers interpret all elements of the diagram.","necessary_changes":null,"optional_changes":null}