Figure: USP22 activation of IRF3 via KPNA2 stabilization (Human)¶
This diagram illustrates the USP22 activation of IRF3 via KPNA2 stabilization pathway in human cells. The pathway spans multiple cellular compartments (cytoplasm, nuclear membrane, nucleus, and mitochondrion) and involves five key proteins:
- TRAF3 (ubiquitin transferase) in the mitochondrion activates TBK1
- TBK1 (protein kinase) in the cytoplasm phosphorylates KPNA2
- USP22 (deubiquitinase) in the cytoplasm deubiquitinates KPNA2, stabilizing it
- KPNA2 (nuclear import receptor) at the nuclear membrane facilitates IRF3 nuclear import
- IRF3 (transcription factor) in the nucleus activates type I interferon production
The pathway represents a mechanism for regulating type I interferon production via control of nuclear transport. Each protein contributes to a signaling cascade that ultimately leads to interferon gene expression, which is critical for antiviral immune responses.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the USP22 pathway for IRF3 activation via KPNA2 stabilization. The cellular compartments are clearly delineated with distinct color coding, making it easy to identify the spatial organization of the signaling pathway. Each protein is well-labeled with both its name and function, and the interactions between proteins are shown with bold directional arrows that clearly indicate the flow of signaling. The improved line thickness enhances visibility, making this suitable for publication in scientific journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}