Figure: Insulin receptor signaling pathway 1 (Mouse)¶
This figure illustrates the insulin receptor signaling pathway in mouse cells. The pathway begins with insulin ligands (Ins1 and Ins2) in the extracellular space binding to insulin receptors (Insr) on the plasma membrane. This triggers receptor autophosphorylation and activation of tyrosine kinase activity, initiating a signaling cascade involving adapter proteins SHC1 and Grb2. These recruit the guanine nucleotide exchange factor Sos1, which activates the small GTPase Hras. This leads to sequential activation of a kinase cascade including Raf1 (serine/threonine kinase), Map2k1 (MAP kinase kinase), and ultimately the MAP kinases Mapk1 and Mapk3 (also known as ERK2 and ERK1). Color coding distinguishes between different protein classes: orange for ligands, blue for receptors, purple for adaptor proteins, green for GEF proteins, and pink for kinases. All molecular components and relationships depicted are derived directly from the GO-CAM model, representing a simplification of the complex insulin signaling network that regulates glucose metabolism.
Feedback from AI on figure:
{"feedback":"The insulin receptor signaling pathway diagram effectively communicates the key components and relationships in this biological process. The illustration uses a clear visual hierarchy with appropriate color coding to distinguish different protein types (ligands, receptors, adaptors, GEFs, and kinases). The pathway flow is logically organized, showing how the signal propagates from extracellular insulin binding through the membrane receptor to the intracellular signaling cascade.\n\nThe drawing has several strengths:\n1. Clear compartmentalization of cellular spaces (extracellular, membrane, cytoplasm)\n2. Consistent and meaningful color scheme with an explanatory legend\n3. Proper labeling of proteins and incorporation of relevant GO terms\n4. Appropriate arrow connectors showing direction of signal flow\n5. Clean, publication-ready aesthetic suitable for journals like Cell or Nature\n\nThe illustration successfully balances scientific accuracy with visual clarity, making it accessible to both specialists and those with general knowledge of cell signaling pathways.","necessary_changes":null,"optional_changes":null}