Figure: HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus)¶
This figure illustrates the HHV1-US3 inhibition of host RIG-I signaling pathway in human cells. The viral US3 protein (P04413) inhibits RIG-I (O95786), a pattern recognition receptor that normally activates TRIM25 (Q14258), which in turn activates MAVS (Q7Z434) at the mitochondrial membrane. Green arrows indicate activation, red X marks indicate inhibition, and dashed lines represent downstream pathways. This pathway demonstrates the viral strategy for evading host innate immunity by suppressing the cytoplasmic pattern recognition receptor signaling.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the HHV1-US3 inhibition of host RIG-I signaling pathway in a publication-quality format. The visual elements clearly differentiate between viral and host proteins, with distinctively marked activation and inhibition pathways using colored arrows and appropriate symbols. The increased line weights enhance pathway visibility, and all text elements are properly sized for readability. The cellular compartments are well-defined, and the relationship between proteins accurately reflects the GO-CAM model. The legend comprehensively explains all graphical elements used in the illustration.","necessary_changes":null,"optional_changes":null}