Figure: Insulin receptor signaling pathway 2 (Mouse)¶
The diagram depicts the insulin receptor signaling pathway in mouse (GO:0008286). The signaling cascade begins with insulin (Ins1/Ins2) binding to insulin receptor (Insr), activating its tyrosine kinase activity. Activated Insr phosphorylates adaptor proteins IRS1/IRS2, which then activate PI3K (composed of Pik3r1 regulatory and Pik3ca catalytic subunits). PI3K converts membrane phospholipids to PIP3 (an implicit step not directly specified in the GO-CAM model, marked with *). PIP3 recruits PDPK1 to the membrane, which phosphorylates and activates AKT1, completing this segment of the signaling pathway. Solid arrows represent direct activation events, while dashed arrows indicate implicit steps added for clarity but not explicitly defined in the source GO-CAM model.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the insulin receptor signaling pathway in mouse with clarity and scientific accuracy. The organization follows the conventional top-down flow of signaling, with clear distinction between extracellular and intracellular components separated by a well-defined cell membrane. The color coding and consistent visual style help differentiate between component types (receptors, adaptors, kinases), while phosphorylation events are clearly marked with red 'P' symbols. The addition of the implicit PIP3 step (appropriately labeled as such) enhances understanding of the pathway mechanism without misrepresenting the source data. Text is readable and proportionately sized, with protein names prominently displayed and GO terms included for reference. The comprehensive legend allows readers to interpret all visual elements effectively.","necessary_changes":null,"optional_changes":"Adding downstream cellular effects of AKT1 activation would provide more functional context, though this may be beyond the scope of the provided GO-CAM model."}