Figure: Gluconeogenesis 3 (Mouse)¶
This diagram depicts the gluconeogenesis pathway in mouse (Mus musculus).
The pathway spans three cellular compartments: - Mitochondrion (green reactions): Begins with pyruvate conversion to oxaloacetate by pyruvate carboxylase (Pcx) and subsequent transamination by aspartate aminotransferase (Got2) - Transport across membranes (purple dashed arrows): Metabolites cross from mitochondria to cytosol via specific transporters (Slc25a12, Slc25a13, Slc25a11) - Cytosol (blue reactions): Series of enzymatic steps converting oxaloacetate to glucose-6-phosphate - Endoplasmic reticulum (orange reactions): Final processing where glucose-6-phosphate is transported into ER by Slc37a4 and dephosphorylated by glucose-6-phosphatases (G6pc1, G6pc3) to yield glucose
Key metabolites in the pathway include pyruvate, oxaloacetate, phosphoenolpyruvate (PEP), 2-phosphoglycerate (2-PG), 3-phosphoglycerate (3-PG), 1,3-bisphosphoglycerate (1,3-BPG), glyceraldehyde 3-phosphate (G3P), dihydroxyacetone phosphate (DHAP), fructose-1,6-bisphosphate (F-1,6-BP), fructose-6-phosphate (F-6-P), and glucose-6-phosphate (G-6-P).
All enzymes and transporters shown are derived directly from the GO-CAM model, with their subcellular localizations represented accurately based on the provided data.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the gluconeogenesis pathway in mouse with clear organization across different cellular compartments. The color-coded reactions enhance readability by visually distinguishing processes occurring in the mitochondria (green), during membrane transport (purple), in the cytosol (blue), and in the endoplasmic reticulum (orange). The inclusion of both gene symbols and common enzyme names improves accessibility while maintaining scientific accuracy. Metabolite labels help track the progression through the pathway, and the enlarged text in the legend improves readability. The overall presentation is polished and appropriate for a scientific journal publication.","necessary_changes":null,"optional_changes":null}