Figure: Insulin-like growth factor receptor signaling pathway 2 (Mouse)¶
This figure illustrates the insulin-like growth factor receptor signaling pathway in mice. The pathway begins with IGF2 binding to the IGF1R receptor at the plasma membrane, which activates the receptor's protein tyrosine kinase (PTK) activity. This initiates a signal transduction cascade that involves multiple adapter proteins (SHC1, GRB2) and exchange factors (SOS1). SOS1 activates the KRAS GTPase, which then triggers the MAPK cascade via RAF1 (MAPKKK). The pathway branches at RAF1, activating both the canonical MAP2K1/MAP2K2-MAPK1/MAPK3 pathway and an alternative MAP2K5-MAPK7 pathway. Different protein families are represented by distinct shapes and colors as shown in the legend. The ATP to ADP conversion that occurs during phosphorylation events is indicated at the IGF1R receptor.
Feedback from AI on figure:
{"feedback":"This scientific illustration effectively captures the insulin-like growth factor receptor signaling pathway in mice as described in the GO-CAM model. The drawing maintains a professional aesthetic suitable for publication in journals like Cell or Nature.\n\nThe diagram clearly shows the signaling cascade from the extracellular IGF2 binding to IGF1R, through the various adapter proteins (SHC1, GRB2), to the activation of downstream kinase cascades. The use of different shapes and colors for different protein types (receptors, adaptors, kinases) enhances clarity, while the inclusion of cellular compartments provides biological context.\n\nThe highlighting of the MAP2K5-MAPK7 alternative pathway branch with different colors and a dashed connection line draws appropriate attention to this specific signaling route. The font sizes are appropriate for readability, and the uniform spacing between elements creates a balanced composition.\n\nThe comprehensive legend ensures that readers can easily interpret the various components and their relationships within the pathway.","necessary_changes":null,"optional_changes":null}