Figure: Insulin-like growth factor receptor signaling pathway 3 (Mouse)¶
This figure depicts the insulin-like growth factor receptor signaling pathway in mouse cells (Mus musculus) as described in the GO-CAM model. The pathway begins in the extracellular space where IGF1 (Igf1) binds to the insulin-like growth factor receptor (IGF1R) embedded in the cell membrane. This binding triggers receptor autophosphorylation through its protein tyrosine kinase activity. The activated IGF1R then recruits and phosphorylates the adaptor protein IRS1, which in turn activates the PI3K complex, consisting of the regulatory subunit PIK3R1 (which has kinase activator activity) and the catalytic subunit PIK3CA (which has PI3K activity). Following PI3K activation, 3-phosphoinositide-dependent protein kinase PDPK1 is activated, which subsequently phosphorylates and activates AKT1, a protein serine kinase that represents the final step in this signaling cascade. Red circles with "P" indicate phosphorylation sites. The pathway components are arranged to show the sequential activation events from receptor binding through signal transduction.
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{"feedback":"This SVG drawing effectively illustrates the insulin-like growth factor receptor signaling pathway in mouse cells. The diagram follows publication-quality standards suitable for journals like Cell or Nature with its clear layout, appropriate use of colors, and professional labeling. The pathway flow is logically arranged, showing the progression from extracellular IGF1 binding through the membrane-bound IGF1R receptor to the downstream signaling cascade involving IRS1, PI3K complex (PIK3R1 and PIK3CA), PDPK1, and ultimately AKT1. All components are clearly labeled with both their protein names and mouse-specific gene identifiers (Mmus). The molecular functions are also appropriately indicated. Phosphorylation events are highlighted with red circles and 'P' labels, and the diagram includes clear demarcation of cellular compartments.","necessary_changes":null,"optional_changes":null}