Figure: FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus)¶
The diagram illustrates the pathway through which Foot-and-Mouth Disease Virus (FMDV) protein 3A (P03305) inhibits host IRF3 via DDX56, suppressing type I interferon production. This represents a viral mechanism to evade host immune responses.
Key pathway components: - FMDV-3A (P03305): Viral protein with molecular adaptor activity in the host nucleus - DDX56 (Q9NY93): Host protein with protein sequestering activity - IPO5 (O00410): Host nuclear import signal receptor at the nuclear membrane - TBK1 (Q9UHD2): Host protein serine/threonine kinase in the cytoplasm - IRF3 (Q14653): Host DNA-binding transcription factor in chromatin
The pathway shows how FMDV-3A positively regulates DDX56, which in turn negatively regulates IPO5. Under normal conditions, TBK1 positively regulates IPO5, which facilitates IRF3 transport to the nucleus where it activates interferon gene expression. By inhibiting this pathway, the virus suppresses the host antiviral response.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the FMDV-3A inhibition pathway through a clear and visually organized representation. The use of distinct colors helps differentiate between viral and host proteins, while the different cellular compartments (cytoplasm and nucleus) are well-delineated. The regulatory relationships are clearly shown through directional arrows and +/- symbols, with a helpful legend explaining these elements. The molecular functions of each protein are labeled appropriately, and the overall pathway flow logically represents how the virus suppresses the host's type I interferon production through this mechanism.","necessary_changes":null,"optional_changes":null}