Figure: Regulation of energy homeostasis by OTUD3 (Human)¶
This pathway diagram illustrates the regulation of energy homeostasis by OTUD3 in humans. The cellular components are divided into cytoplasm (top) and nucleus (bottom, blue ellipse). Three key proteins are shown:
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CREBBP (Q92793) in the cytoplasm has peptide-lysine-N-acetyltransferase activity and performs N-terminal peptidyl-lysine acetylation.
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OTUD3 (Q5T2D3) in the nucleus has cysteine-type deubiquitinase activity and performs protein K48-linked deubiquitination.
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PPARD (Q03181) in the nucleus has DNA-binding transcription factor activity and regulates transcription by RNA polymerase II.
The red arrow with "+" indicates positive regulation from CREBBP to OTUD3, while the blue arrow with "+" shows positive regulation from OTUD3 to PPARD. The black arrow shows the process flow from PPARD to energy homeostasis. This pathway demonstrates how OTUD3 functions as an intermediary in the regulation of energy homeostasis, with CREBBP acting as an upstream regulator and PPARD as a downstream effector.
Feedback from AI on figure:
{"feedback":"The diagram effectively communicates the regulatory pathway of energy homeostasis by OTUD3. The key improvements in this version include clear separation of overlapping text in the 'Protein K48-linked deubiquitination' label by using two lines instead of one, increased font sizes throughout for better readability, distinct colors for different regulatory arrows, expanded legend that clearly explains the different arrow types, and better spacing of elements throughout the diagram for improved visual clarity. The cellular compartments are clearly delineated with the cytoplasm and nucleus properly labeled, and the protein functions and biological processes are accurately represented. The flow from CREBBP to OTUD3 to PPARD leading to energy homeostasis is logically depicted with appropriate directional arrows and regulatory symbols.","necessary_changes":null,"optional_changes":null}