Figure: Insulin-like growth factor receptor signaling pathway 4 (Mouse)¶
The diagram illustrates the Insulin-like Growth Factor Receptor signaling pathway in mouse, starting with IGF2 binding to IGF1R at the cell membrane. Upon ligand binding, IGF1R uses ATP to phosphorylate IRS1, releasing ADP in the process. Phosphorylated IRS1 activates PIK3R1, which forms a complex with PIK3CA (together forming the PI3K complex). This complex activates PDPK1, which in turn phosphorylates and activates AKT1, the final kinase in this signaling cascade. The pathway flows from extracellular space through the membrane into the cytoplasm, with each protein conducting specific molecular functions: IGF2 (receptor ligand), IGF1R (receptor tyrosine kinase), IRS1 (receptor adaptor), PIK3R1 (kinase activator), PIK3CA (phosphatidylinositol kinase), PDPK1 (3-phosphoinositide-dependent kinase), and AKT1 (protein serine kinase).
Feedback from AI on figure:
{"feedback":"The diagram clearly and effectively illustrates the Insulin-like Growth Factor Receptor signaling pathway in mice. The visual representation includes all key components from the GO-CAM model, with proteins arranged in a logical sequence showing signal transduction from the cell membrane to intracellular effectors. The use of distinctive colors and shapes helps differentiate between pathway components, while the increased font size and text weight improve readability. The cellular compartmentalization (extracellular space vs. cytoplasm) provides important spatial context for the signaling events. Phosphorylation events are well-marked, and the inclusion of ATP/ADP exchange illustrates the energetic component of the signaling process. Overall, the diagram successfully captures the essence of this signaling pathway in a format suitable for publication in a scientific journal.","necessary_changes":null,"optional_changes":null}