Figure: HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus)¶
This diagram illustrates how the Human Cytomegalovirus (HCMV) protein UL145 inhibits the host antiviral response by targeting STAT2 for degradation. UL145 promotes the interaction of DDB1 with CUL4A, forming an E3 ubiquitin ligase complex with RBX1. This complex ubiquitinates STAT2, leading to its degradation and preventing STAT2 from activating the Type I Interferon signaling pathway - a key component of the host antiviral response. Color coding indicates viral proteins (red), E3 ligase components (green), transcription factors (blue), and signaling pathways (light blue). Different line styles represent various interaction types including binding, ubiquitination, and inhibition.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the HCMV-UL145 inhibition pathway of STAT2 via DDB1/CUL4A in a clear, scientifically accurate manner suitable for publication in high-impact journals. The visual elements are well-designed with appropriate color coding to distinguish between viral proteins, host cellular components, and signaling pathways. The interactions between proteins are clearly depicted with different arrow styles and accompanying text labels that explain the nature of each interaction. The addition of abbreviation explanations makes the diagram accessible to readers with varying levels of subject knowledge. The cellular compartmentalization showing these interactions within the nucleus provides important spatial context for understanding the mechanism.","necessary_changes":null,"optional_changes":null}