Figure: Insulin receptor recycling (Mouse)¶
The diagram illustrates the Insulin Receptor Recycling Pathway in mice. Key steps include:
- Insulin binding to Insulin Receptor (INSR) at the plasma membrane, facilitated by SORL1
- Internalization into early endosomes where Insulin Degrading Enzyme (IDE) begins processing
- Progression to late endosomes where Cathepsin D (CTSD) continues insulin degradation
- Transport to recycling endosomes
- Recycling of insulin receptor back to the plasma membrane
The V-ATPase complex (V0 and V1 domains) is activated by ATP6AP1 and acidifies the endosomal lumen, which is crucial for proper function of degradative enzymes. Protein tyrosine phosphatases (PTPN1 and PTPN2) dephosphorylate the insulin receptor during recycling, preparing it for another round of signaling.
Color coding: - Red pathway: Insulin internalization - Green pathway: Receptor recycling - Yellow dashed lines: Dephosphorylation events - Blue pathway: Endosome progression - Orange pathway: V-ATPase activation
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the insulin receptor recycling pathway in mouse cells with excellent clarity and scientific accuracy. The color-coded pathways and numbered steps make the process flow easy to follow, even for those less familiar with the pathway. The legend provides clear explanations of both the symbols and the biological process.\n\nKey strengths include:\n1. Clear visual distinction between different cellular compartments (plasma membrane, early/late/recycling endosomes)\n2. Appropriate representation of all key proteins mentioned in the source material\n3. Logical flow of the pathway with directional arrows\n4. Professional appearance suitable for publication in scientific journals\n\nThe numbered steps and color-coding add pedagogical value without compromising scientific accuracy, making this illustration both informative and accessible.","necessary_changes":null,"optional_changes":null}