Figure: PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus)¶
This diagram illustrates how the Paramyxovirus (PIV5) V protein inhibits STAT1 via the DDB1/CUL4A complex, thereby disrupting type I interferon signaling.
The pathway depicts five main steps: 1. The viral PIV5-V protein acts as an adaptor protein 2. DDB1 and CUL4A form a complex with PIV5-V 3. RBX1 provides ubiquitin ligase activity to the complex 4. STAT1 is targeted for ubiquitination and degradation 5. The degradation of STAT1 prevents its DNA-binding transcription factor activity in the nucleus
Cellular compartments are represented with different background colors - light blue for the cytoplasm and light green for the nucleus. The pathway demonstrates how viral proteins can hijack host cellular machinery to evade immune responses, specifically the type I interferon-mediated signaling pathway.
Feedback from AI on figure:
{"feedback":"The final diagram effectively illustrates the PIV5-V inhibition of STAT1 via the DDB1/CUL4A complex in a clear, visually appealing manner suitable for publication in journals like Cell or Nature. The improvements made to the original drawing include:\n\n1. Enhanced visual clarity with directional arrows showing the pathway flow\n2. Distinct color coding for different types of interactions (direct vs. indirect)\n3. Numbered steps that guide the viewer through the process\n4. Improved contrast and distinctive shapes for different molecular components\n5. Clear cellular compartmentalization showing cytoplasm and nucleus\n6. Well-organized legend explaining all visual elements\n\nThe diagram successfully captures the biological process while maintaining scientific accuracy and visual appeal. The connection between the virus and its impact on host cellular machinery is clearly conveyed, making this diagram effective for communicating complex molecular interactions to both specialists and broader scientific audiences.","necessary_changes":null,"optional_changes":null}