Figure: Regulation of oolemmal binding multimeric complex formation (Mouse)¶
This figure illustrates the regulation of oolemmal binding multimeric complex formation in mouse, depicting the molecular pathway that contributes to fertilization. The diagram shows interactions between proteins in different cellular compartments:
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In the sperm endoplasmic reticulum membrane (ER), Sppl2c (aspartic protease) positively regulates Frey1 (protein adaptor) and Pln (ATPase inhibitor). Frey1 negatively regulates Sppl2c protease activity. Pln functions in calcium homeostasis.
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Frey1 positively regulates the sperm surface protein Izumo1 (receptor ligand), which is essential for gamete recognition.
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In the sperm acrosome, Glipr1l1 positively regulates Izumo1 localization and function.
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Izumo1 on the sperm membrane binds to Izumo1r on the egg membrane, mediating sperm-egg recognition (GO:0035036) during fertilization.
The diagram uses color-coded arrows to distinguish between positive regulation (blue), negative regulation (red dashed), and functional activities (green). All proteins and processes shown are derived from the GO-CAM model.
Feedback from AI on figure:
{"feedback":"The final diagram effectively illustrates the regulation of oolemmal binding multimeric complex formation in mouse reproduction, providing a clear scientific visualization suitable for a journal publication. The cellular compartmentalization is well-represented, showing the ER membrane in sperm, the acrosome, and the interface between sperm and egg plasma membranes. The proteins (Sppl2c, Frey1, Pln, Glipr1l1, Izumo1, and Izumo1r) are clearly labeled with their molecular functions, and the regulatory relationships between them are indicated with colored and styled arrows that distinguish between positive regulation, negative regulation, and functional activities. The addition of GO terms provides important context for scientific accuracy. The spaced layout and color-coding enhance readability and make the biological pathway easy to follow from ER activities to fertilization.","necessary_changes":null,"optional_changes":null}