Figure: Positive regulation of insulin secretion 8 (Mouse)¶
This diagram illustrates the positive regulation of insulin secretion in mouse pancreatic beta cells (CL:0000169). The signaling cascade begins with GIP (Gastric Inhibitory Peptide) binding to its receptor GIPR at the plasma membrane, activating the G protein Gnas. Activated Gnas stimulates adenylate cyclase (Adcy8), which converts ATP to cAMP and PPi. cAMP activates Rapgef4, which functions as both a guanyl-nucleotide exchange factor and protein adaptor. Rapgef4 activates the small G protein Rap1b, which signals to Rims2, a protein adaptor. Rims2 interacts with Rab3a (another protein adaptor), ultimately leading to insulin secretion (GO:0030073). This entire process is part of the adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189).
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{"feedback":"The diagram effectively illustrates the positive regulation of insulin secretion in mouse pancreatic beta cells. It captures all key components from the GO-CAM model, showing how the signaling cascade progresses from GIP ligand binding through G-protein activation, cAMP production, and the downstream effects on insulin secretion machinery. The drawing is carefully organized to show spatial relationships, with clear demarcation between extracellular space, plasma membrane, and cytosol compartments. Molecular functions are annotated throughout, providing context for each protein's role in the pathway. The inclusion of GO terms provides scientific precision, while the use of consistent color coding with bold protein names enhances readability. The pathway arrows are clearly visible with appropriate thickness, and the cellular components are represented in a visually intuitive way.","necessary_changes":null,"optional_changes":null}