Figure: mRNA editing enabled by APOBEC1 (Human)¶
This diagram illustrates the mRNA editing process enabled by APOBEC1 in human cells, specifically the cytidine-to-uridine editing of APOB mRNA within the nucleus.
Key components: - RBM47 and A1CF (orange proteins): Act as enzyme-substrate adaptors (GO:0140767) that guide APOBEC1 to the editing site on APOB mRNA - APOBEC1 (blue protein): Performs cytidine deaminase activity (GO:0004126) to convert cytidine (C) to uridine (U) - The editing process occurs within the nucleus (GO:0005634) and represents cytidine to uridine editing (GO:0016554) - C→U conversion: The deamination reaction chemically transforms cytidine to uridine
Consequences: - Unedited mRNA produces APOB100, which functions in LDL receptor binding (GO:0050750) - Edited mRNA contains a premature stop codon, resulting in the truncated APOB48 variant, which participates in LDL particle clearance (GO:0034383)
The diagram shows UniProt identifiers for all proteins (A0AV96 for RBM47, Q9NQ94 for A1CF, P41238 for APOBEC1, and P04114 for APOB).
Feedback from AI on figure:
{"feedback":"The diagram clearly illustrates the mRNA editing process enabled by APOBEC1 in human cells. It shows the key proteins (RBM47, A1CF, and APOBEC1) and their roles in the cytidine-to-uridine editing of APOB mRNA, along with the resulting protein variants (APOB100 and APOB48) and their different functions. The improved formatting enhances readability with better color-coding, bolder text, clearer labels, more prominent arrows, and consistent visual language. The diagram is suitable for publication in a high-quality journal like Cell or Nature, with clear scientific accuracy while maintaining visual elegance.","necessary_changes":null,"optional_changes":null}