Figure: HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus)¶
This diagram illustrates the mechanism by which Herpes Simplex Virus 1 (HHV1) protein US11 inhibits host cell autophagy. The pathway shows viral US11 protein (red) inhibiting TRIM23, disrupting a signaling cascade where normally TRIM23 activates TBK1, which in turn activates SQSTM1, ultimately promoting autophagy. Green arrows indicate activation, while red arrows represent inhibition. All interactions occur in the host cell cytoplasm and represent molecular activities documented in the GO-CAM model.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the pathway by clearly highlighting the interactions between US11, TRIM23, TBK1, and SQSTM1. The color coding and arrows are used effectively to demonstrate the direction and type of regulation (positive or negative) that occurs in the pathway. Each protein's role and designation are clearly labeled with relevant biological activities, ensuring clarity in the molecular interactions involved. The placement within the host cell is visually clear, making it easy for readers to grasp the context of the viral infection and suppression of autophagy.","necessary_changes":null,"optional_changes":null}