Figure: USP20-mediated STING deubiquitination leading to STING stabilisation (Human)¶
Legend: - USP18 (green hexagon): Acts as a molecular adaptor in the cytoplasm - USP20 (orange rounded rectangle): Functions as a deubiquitinase in the cytoplasm - STING1 (blue oval): Binds 2',3'-cyclic GMP-AMP at the endoplasmic reticulum membrane - Green circle with "+" sign: Indicates positive regulation - Yellow circles: Represent ubiquitin molecules that are removed by USP20 - Orange oval: Represents cGAMP molecule that binds to STING1
Pathway steps: 1. USP18 recruits and positively regulates USP20 in the cytoplasm 2. USP20 removes ubiquitin from STING1, stabilizing it 3. Stabilized STING1 at the ER membrane can bind cGAMP 4. This pathway is part of the antiviral innate immune response
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the USP20-mediated STING deubiquitination pathway with clear visual hierarchy and organization. The use of different geometric shapes for each protein (hexagon for USP18, rounded rectangle for USP20, and oval for STING1) aids in quick visual identification, complemented by consistent color coding. The addition of process annotations explaining each step makes the diagram more accessible to readers with varying levels of familiarity with the topic. The pathway flow is clearly indicated with directional arrows and positive regulation symbols. The cellular compartments (cytoplasm and ER membrane) are visually distinct, helping readers understand the spatial context of these interactions. The inclusion of molecular details like ubiquitin removal and cGAMP binding enhances the scientific accuracy while maintaining clarity. The comprehensive legend ensures all visual elements are properly explained.","necessary_changes":null,"optional_changes":null}