Figure: Positive regulation of insulin secretion 11 (Mouse)¶
This diagram illustrates the positive regulation of insulin secretion in mouse pancreatic beta cells (GO-CAM model 633b013300000089). The pathway begins with the G protein-coupled receptor Ffar2 (MGI:2441731) in the plasma membrane, which activates G proteins Gna11 (MGI:95766) and Gnaq (MGI:95776). These G proteins activate phospholipase C beta 1 (Plcb1, MGI:97613), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) and water to produce diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 binds to and activates the IP3 receptor (Itpr1, MGI:96623), which releases calcium from intracellular stores. The increased cytosolic calcium concentration triggers insulin secretion from the beta cell.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the positive regulation of insulin secretion pathway in mouse pancreatic beta cells as described in the GO-CAM model. The pathway components are clearly represented with appropriate shapes, colors, and labels that follow scientific convention. The flow of the signaling cascade is well-depicted with directional arrows and annotations describing the relationships between components. The inclusion of both gene names and their functions enhances understanding for readers with different levels of familiarity with the pathway.","necessary_changes":null,"optional_changes":null}