Figure: Tricarboxylic acid cycle 1 (Mouse)¶
This figure illustrates the Tricarboxylic Acid (TCA) Cycle in mouse mitochondria. The cycle is shown within the mitochondrial matrix (beige oval) with metabolites (blue circles) and enzymes/enzyme complexes (blue rectangles) arranged in a circular pathway. Arrows indicate reaction directionality and enzyme catalysis. Key components include: citrate synthase (Cs), aconitase (Aco2), isocitrate dehydrogenase complex (Idh3a, Idh3b, Idh3g), 2-oxoglutarate dehydrogenase complex (Ogdh, Dld, Dlst), succinate-CoA ligase complexes (GDP and ADP-forming variants), succinate dehydrogenase/Complex II (Sdha, Sdhb, Sdhc, Sdhd), fumarase (Fh1), and malate dehydrogenase (Mdh2). The regulatory protein Sirt3 is shown activating Complex II through deacetylation (dashed red arrow). Important cofactors NAD+/NADH, CoA, GDP/GTP, and ADP/ATP participate in various steps of the cycle. External input of Acetyl-CoA (orange circle) feeds into the cycle.
Feedback from AI on figure:
{"feedback":"This scientific illustration effectively captures the Tricarboxylic Acid Cycle in mouse mitochondria with exceptional clarity and accuracy. The circular arrangement of metabolites and enzymes within the mitochondrial matrix creates an intuitive representation of this cyclical pathway. Each enzyme and enzyme complex is clearly labeled with both protein names and their functional activities, while metabolites are prominently displayed with bold text for easy identification.\n\nThe diagram successfully conveys the sequential nature of the reactions through well-positioned directional arrows, allowing viewers to follow the pathway progression. The use of distinct yet complementary colors differentiates between metabolites, single enzymes, enzyme complexes, and regulatory elements. The regulatory role of Sirt3 on Complex II is appropriately indicated with a dashed line, showing biological regulation rather than direct metabolic conversion.\n\nThe inclusion of a comprehensive legend and cofactor box enhances the educational value of the illustration, making it suitable for a high-quality scientific journal. Text size has been optimized for readability, and the overall layout maintains professional aesthetics while conveying complex biochemical information in an accessible format.","necessary_changes":null,"optional_changes":null}