Figure: Pyruvate catabolic process 2 (Mouse)¶

Figure: Pyruvate catabolic process in mouse mitochondria

This diagram illustrates the pyruvate dehydrogenase (PDH) complex pathway in mouse cells, showing the transport of pyruvate from the cytosol into mitochondria and its subsequent conversion to acetyl-CoA.

The process begins with cytosolic pyruvate entering the mitochondrion through VDAC1 (Voltage-dependent anion channel 1) in the outer mitochondrial membrane. Pyruvate then crosses the inner membrane via the pyruvate carrier complex (MPC1/MPC2). In the mitochondrial matrix, the pyruvate dehydrogenase complex (PDH) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA.

The PDH complex consists of multiple components: - PDHA1/2 (E1α) and PDHB (E1β): Form the pyruvate decarboxylase component - DLAT (E2): Provides acetyltransferase activity - DLD (E3): Functions as dihydrolipoyl dehydrogenase - PDHX (E3BP): Serves as a molecular adaptor

This pathway is central to cellular energy metabolism, connecting glycolysis to the TCA cycle through the production of acetyl-CoA.

Feedback from AI on figure:

{"feedback":"The diagram effectively represents the pyruvate catabolic pathway in mouse mitochondria with clear visual organization and scientific accuracy. The cellular compartmentalization is well-defined, showing the cytosol, mitochondrial outer and inner membranes, intermembrane space, and matrix with appropriate GO terms. The pathway flow is logically represented with arrows indicating the movement of pyruvate from the cytosol through the membranes via specific transporters (VDAC1, MPC1/2) and its subsequent processing by the pyruvate dehydrogenase complex to form acetyl-CoA. The components of the PDH complex (PDHA1/2, PDHB, DLAT, DLD, and PDHX) are appropriately displayed with their respective molecular functions. The color coding and legend enhance clarity and make the diagram suitable for publication in a high-impact journal.","necessary_changes":null,"optional_changes":null}