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Figure: Granzyme-mediated (GZMA) activation of pyroptosis (GSDMB isoform 4) (Human)

id: gomodel:6348a65d00000594

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This figure illustrates the pathway of Granzyme A (GZMA)-mediated activation of pyroptosis via Gasdermin B isoform 4 (GSDMB-4) in human cells. The process involves:

  1. A cytotoxic T cell releases Perforin (PRF1) and Granzyme A (GZMA)
  2. PRF1 forms pores in the target cell's plasma membrane (GO:0071806 - protein transmembrane transport)
  3. GZMA enters the cytoplasm and cleaves/activates GSDMB isoform 4 (GO:0051604 - protein maturation)
  4. Activated GSDMB-4 binds to phospholipids in the plasma membrane (GO:0005543 - phospholipid binding) and forms pores, triggering pyroptotic cell death (GO:1902483 - cytotoxic T cell pyroptotic cell death)

Colors indicate different proteins: PRF1 (red), GZMA (green), and GSDMB-4 (blue). Active GSDMB-4 is highlighted with a red border to distinguish it from its inactive form. Numbered circles indicate the sequence of events.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the Granzyme-mediated activation of pyroptosis pathway in a style suitable for a high-impact journal. The key strengths include:\n\n1. Clear visual distinction between the cytotoxic T cell and the target cell\n2. Logical flow of the process with numbered steps that guide the reader through the pathway\n3. Appropriate use of colors and shapes to distinguish different molecular components\n4. Well-organized legend that explains both the proteins and the Gene Ontology terms\n5. Semi-transparent backgrounds for GO terms that improve readability without cluttering the diagram\n\nThe illustration accurately represents the GO-CAM data while presenting it in an accessible, publication-ready format that effectively communicates the biological process of GZMA-mediated pyroptosis via GSDMB activation.","necessary_changes":null,"optional_changes":null}