Figure: Regulation by IL22 and Reg3g of allergic airway inflammation. (Mouse)¶
This illustration depicts the regulation of allergic airway inflammation by IL22 and Reg3g in mice. The pathway shows how CD4+ T cells produce IL22, which binds to IL22RA1 on lung epithelial cells. This activates STAT3 in the nucleus, leading to the production of Reg3g. Reg3g binds to EXTL3 receptors, inhibiting the production of pro-inflammatory cytokines IL33 and TSLP. While IL33 and TSLP promote inflammatory responses, IL22 and Reg3g work together to negatively regulate inflammatory responses, providing a protective mechanism against allergic airway inflammation.
Feedback from AI on figure:
{"feedback":"The final drawing effectively illustrates the regulation of allergic airway inflammation through IL22 and Reg3g in mouse models. The diagram clearly communicates the molecular pathway, showing how CD4+ T cells produce IL22, which activates STAT3 in lung epithelial cells via IL22RA1 to produce Reg3g. The inhibitory effect of Reg3g (via EXTL3) on pro-inflammatory cytokines IL33 and TSLP is well-depicted with dashed lines. The use of different colors, shapes, and line styles enhances readability and understanding of the different components and their interactions. The comprehensive legend further clarifies the meaning of visual elements used in the diagram, making it publication-ready for journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}