Figure: Regulation by IL22 and REG3A of allergic airway inflammation. (Human)¶
The figure depicts the regulation of allergic airway inflammation by IL-22 and REG3A in humans. In this pathway, CD4+ T cells produce IL-22, which is secreted into the extracellular space. IL-22 binds to the IL-22RA1 receptor on lung epithelial cells, activating STAT3 signaling in the nucleus. Activated STAT3 induces the production of REG3A, which is then secreted into the extracellular space. REG3A binds to the EXTL3 receptor and inhibits the inflammatory cytokines IL-33 and TSLP, thereby negatively regulating allergic airway inflammation. This illustration faithfully represents the GO-CAM model (gomodel:6348a65d00000848) describing this anti-inflammatory pathway.
Feedback from AI on figure:
{"feedback":"The final diagram effectively illustrates the regulation pathway of allergic airway inflammation by IL-22 and REG3A. The cellular compartments (CD4+ T cell, lung epithelial cell, extracellular space) are clearly delineated with distinct colors and borders. Each protein and molecular interaction is represented with appropriate shapes, colors, and labels that are easily readable. The signaling cascade from IL-22 production to REG3A-mediated inhibition of inflammatory cytokines is logically arranged and clearly indicated with labeled arrows and interaction points. The legend comprehensively explains all components of the pathway, making the diagram suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}