Figure: Negative regulation of inflammatory response to wounding by REG3A. (Human)¶
Legend: - Cytokines (Red circles): IL-33, TNF, IL-6 - REG3A Hormone (Green circle): Mediates negative regulation of inflammatory response - Receptors (Blue rectangles): EXTL3 (hormone receptor), TLR3 (transmembrane signaling receptor) - STAT3 Transcription Factor (Pink triangles): Mediates gene expression in the nucleus - Phosphatase (Orange rounded rectangle): PTPN6, inhibits JNK signaling - Kinase (Purple rounded rectangle): JNK, promotes inflammatory cytokine production
Cell Compartments: - Extracellular Space: Where cytokines and hormone signaling occurs - Plasma Membrane: Location of transmembrane receptors - Cytoplasm: Contains signaling proteins and enzymes - Nucleus: Site of transcriptional regulation
Signaling Pathways: - IL-33 → REG3A → EXTL3 → PI3K/Akt → STAT3 → PTPN6 → inhibition of JNK - TLR3 → JNK cascade → inflammatory cytokines (TNF, IL-6)
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the negative regulation of inflammatory response to wounding by REG3A in human cells. It clearly depicts the signaling pathway from IL-33 activation of REG3A through to the inhibition of inflammatory cytokine production.\n\nThe cellular compartmentalization is well-represented, with clear distinctions between extracellular space, plasma membrane, cytoplasm, and nucleus. The protein interactions are logically arranged and follow the biological sequence of events.\n\nThe use of different colors and shapes helps distinguish between different types of molecules (cytokines, receptors, enzymes, transcription factors), and the directional arrows clearly indicate the flow of signaling and regulatory relationships.\n\nThe pathway summary and legend provide helpful context for understanding the diagram, making it suitable for inclusion in a scientific journal publication.","necessary_changes":null,"optional_changes":null}