Figure: Ascorbic acid biosynthetic process 1 (Mouse)¶
This diagram illustrates the ascorbic acid (Vitamin C) biosynthetic pathway in mouse liver cells. The pathway begins with β-D-glucose 1-phosphate and proceeds through several enzymatic steps to produce L-ascorbate (Vitamin C).
The six key enzymes in this pathway are: 1. Ugp2 (UTP-monosaccharide-1-phosphate uridylyltransferase) 2. Ugdh (UDP-glucose 6-dehydrogenase) 3. Ugt1a6a (alpha-glucuronidase) 4. Akr1a1 (L-glucuronate reductase) 5. Rgn (gluconolactonase) 6. Gulo (L-gulonolactone oxidase)
Each enzyme is shown with a distinct color and labeled with both its gene symbol and enzymatic function. The pathway showcases a linear sequence of reactions that convert the initial substrate through several intermediate metabolites (shown with dashed outlines as they are implicit in the original GO-CAM model) to the final product, L-ascorbate. The entire process occurs within a mouse liver cell as part of the general biosynthetic process (GO:0009058).
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the ascorbic acid biosynthetic pathway in mouse liver cells, presenting a clear visualization of the Gene Ontology Causal Activity Model (GO-CAM). Each enzyme is distinctly color-coded and properly labeled with both gene symbol and function, making it easy to follow the sequential reactions. The representation of implicit intermediates with dashed outlines provides clarity on what was directly specified in the original model versus what was added for completeness. The cellular context is well established with the liver cell outline and nucleus, and the final product is appropriately highlighted.","necessary_changes":null,"optional_changes":"If this were to be refined further, perhaps including some indication of subcellular localization of specific reactions would add another dimension of biological context, as certain enzymes may be associated with specific organelles."}