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Figure: Ascorbic acid biosynthetic process 2 (Mouse)

id: gomodel:6348a65d00002993

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This diagram illustrates the Ascorbic acid biosynthetic pathway in mouse liver cells based on the provided GO-CAM model. The pathway shows the enzymatic conversion of β-D-glucose 1-phosphate to L-ascorbate (Vitamin C) through a series of sequential reactions:

  1. Ugp2 (UTP-monosaccharide-1-phosphate uridylyltransferase) converts β-D-glucose 1-phosphate to UDP-glucose
  2. Ugdh (UDP-glucose 6-dehydrogenase) converts UDP-glucose to UDP-glucuronate
  3. Ugt1a6a (alpha-glucuronidase) converts UDP-glucuronate to glucuronate
  4. Akr1b1 (L-glucuronate reductase) converts glucuronate to L-gulonate
  5. Rgn (gluconolactonase) converts L-gulonate to L-gulonolactone
  6. Gulo (L-gulonolactone oxidase) converts L-gulonolactone to L-ascorbate (Vitamin C)

The intermediate metabolites (shown in dashed yellow boxes) are implied in the pathway but not explicitly mentioned in the GO-CAM model. All reactions take place within the liver cell, which is the primary site of vitamin C biosynthesis in mice. The entire process is part of the larger biosynthetic process (GO:0009058).

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the Ascorbic acid biosynthetic pathway in mice with clear organization and visual hierarchy. The sequential enzymatic reactions are well-represented with appropriate directional arrows showing the flow from β-D-glucose 1-phosphate to L-ascorbate (Vitamin C). \n\nStrengths:\n- Clear distinction between enzymes, substrates, and products using consistent color coding\n- Improved visibility of enzyme names with larger font sizes\n- Clearer indication of the liver cell context\n- Well-designed representation of intermediate metabolites with dashed outline boxes\n- Comprehensive legend explaining all visual elements\n- Appropriate spacing and layout that makes the pathway easy to follow\n\nThe diagram successfully combines scientific accuracy with visual clarity, making it suitable for publication in journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}