Figure: The NLRP3 inflammasome (Human)¶
NLRP3 Inflammasome Pathway: - NLRP3 (Q96P20): Initially functions as a sensor at the cell membrane, then transitions to the microtubule organizing center (MTOC) where it interacts with NEK7. It subsequently moves to the cytosol where it acts as a signaling adaptor, leading to inflammasome complex formation. - NEK7 (Q8TDX7): Located in the MTOC, activates NLRP3 through molecular function activator activity. - CASP1 (P29466): Caspase-1 is activated by the NLRP3 inflammasome complex and acts as a cysteine-type endopeptidase to process pro-inflammatory cytokines. - GSDMD (P57764): Gasdermin D is cleaved by caspase-1 and forms pores in the plasma membrane, enabling cytokine secretion and pyroptotic cell death. - IL-1β (P01584) and IL-18 (Q14116): Pro-inflammatory cytokines processed by caspase-1 and released into the extracellular space through GSDMD pores to initiate inflammatory signaling.
Feedback from AI on figure:
{"feedback":"The diagram successfully illustrates the NLRP3 inflammasome pathway in a style appropriate for a high-impact journal like Cell or Nature. The cellular compartmentalization is clearly depicted, showing the spatial organization of key molecular events. The pathway flow is logical and easy to follow, from initial NLRP3 activation at the membrane through inflammasome formation, cytokine processing, and eventual release through GSDMD pores. The color coding and distinct shapes help differentiate molecule types while maintaining a cohesive visual style. The text is readable and appropriately sized, and the legend provides comprehensive context for understanding the pathway.","necessary_changes":null,"optional_changes":null}