Figure: Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human)¶
This diagram illustrates the activation pathway of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 in human cells, as represented in the GO-CAM model.
Key components: - MAPK8/JNK1 (P45983): A serine/threonine kinase that initiates the pathway - BRCC3 (P46736): A K63-linked deubiquitinase activated by MAPK8 - NLRP3 (Q96P20): A pattern recognition receptor that acts as signaling adaptor and binds phosphatidylinositol-4-phosphate - NLRP3 Inflammasome Complex: The final assembled complex that triggers inflammatory responses
The pathway shows MAPK8 phosphorylating BRCC3, which then deubiquitinates NLRP3 at the microtubule organizing center. NLRP3 then relocates to the membrane where it exhibits signaling adaptor activity and phosphatidylinositol-4-phosphate binding, ultimately leading to inflammasome complex assembly.
Note: ASC (PYCARD) is shown in the inflammasome complex for clarity but is not explicitly mentioned in the GO-CAM source model.
Feedback from AI on figure:
{"feedback":"The diagram effectively uses different shapes to represent various molecule types, maintaining clarity in distinguishing enzymes, scaffolding proteins, and complexes. The pathway is logically laid out with directional arrows that guide the viewer through the sequence of interactions and activations. The text within the shapes is clear, and the use of color coding enhances understanding.\n\nThe legend is comprehensive, providing necessary information about the symbols and their activities, ensuring that viewers can easily interpret the diagram. The cellular compartments are clearly labeled, providing context to the interactions taking place within specific cellular environments.\n\nOverall, the diagram is well-organized and effectively communicates the activation pathway of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3.","necessary_changes":null,"optional_changes":null}