Figure: Cellular response to glucagon stimulus (Mouse)¶
The diagram illustrates the cellular response to glucagon stimulus in mouse hepatocytes. It shows the pathway from glucagon (Gcg) binding to its receptor (Gcgr) at the plasma membrane, activating G protein (Gnas), which then activates adenylate cyclase (Adcy8). This leads to the production of cAMP (implied), which binds to the PKA holoenzyme, causing dissociation of the regulatory subunit (Prkar1a) from the catalytic subunit (Prkaca) in the cytosol. Active Prkaca can then mediate downstream effects including glycogen breakdown and gluconeogenesis. Solid colored shapes represent proteins explicitly mentioned in the GO-CAM model, while dashed lines and borders indicate implied components or processes not explicitly stated in the source data but necessary for pathway continuity.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the cellular response to glucagon stimulus in mouse hepatocytes, faithfully representing the GO-CAM model while adding appropriate visual context. The pathway flow is clearly depicted with directional arrows and concise labels that explain the interactions between components. The compartmentalization between plasma membrane and cytosol is well-defined, helping to spatially organize the signaling events. The color coding and comprehensive legend enhance readability by distinguishing between different molecular components, and the dashed lines appropriately indicate implied processes not explicitly mentioned in the source data but necessary for understanding the complete pathway. The figure maintains a clean, publication-ready aesthetic suitable for journals like Cell or Nature.","necessary_changes":null,"optional_changes":"To further enhance the diagram, you might consider adding a subtle indication of the hepatocyte cell type context, though this is not essential as the current representation is already comprehensive and clear."}