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Figure: DCAF12 controls MOV10 during T cell activation. (Human)

id: gomodel:636d9ce800001192

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The diagram illustrates the regulatory pathway of DCAF12 control over MOV10 during T cell activation in humans.

Key components: - MOV10 (pink): RNA helicase involved in miRNA-mediated gene silencing - DCAF12 (green): Functions as a ubiquitin-like ligase-substrate adaptor - CUL4A (blue): Serves as a ubiquitin ligase complex scaffold - RBX1 (purple): Acts as a ubiquitin protein ligase

The pathway shows how these proteins interact in the cytoplasm as part of the ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. CUL4A negatively regulates DCAF12, which positively regulates RBX1. RBX1 then causes ubiquitination of MOV10, affecting its role in miRNA-mediated gene silencing by mRNA destabilization.

Feedback from AI on figure:

{"feedback":"This diagram effectively illustrates the complex pathway of DCAF12's control over MOV10 during T cell activation. The visual representation is clear, precise, and follows journal publication standards. The color-coding of both proteins and interaction arrows greatly enhances readability, allowing viewers to quickly distinguish between different types of regulatory relationships. The relocated legend improves accessibility without cluttering the main pathway visualization.\n\nThe diagram successfully balances scientific accuracy with visual clarity, showing the key proteins (MOV10, DCAF12, CUL4A, and RBX1) and their functional relationships within the appropriate cellular compartment. The ubiquitin-dependent protein catabolic process via the C-end degron rule pathway is clearly depicted, and the role of each protein is succinctly described.","necessary_changes":null,"optional_changes":null}