Figure: DCAF12 controls MOV10 during spermatogeneis. (Human)¶
This diagram depicts the regulation of MOV10 by DCAF12 during human spermatogenesis, based on the GO-CAM model. The pathway occurs in the cytoplasm and cytosol of spermatocytes.
Key components: - CUL4A acts as a scaffold in the ubiquitin ligase complex, positively regulating DCAF12 - DCAF12 functions as a substrate adaptor, forming a causal connection with RBX1 - RBX1 has ubiquitin protein ligase activity and negatively regulates MOV10 - MOV10 possesses RNA helicase activity and is involved in miRNA-mediated gene silencing
The diagram shows how CUL4A, DCAF12, and RBX1 participate in the ubiquitin-dependent protein catabolic process via the C-end degron rule pathway, leading to the degradation of MOV10 (indicated by ubiquitin tags). This regulation occurs as part of spermatogenesis.
Symbols: - Yellow circles labeled "Ub": Ubiquitin tags - "+" sign: Positive regulation - "-" sign: Negative regulation - Arrows: Direction of causal associations
Feedback from AI on figure:
{"feedback":"The diagram effectively conveys the pathway for DCAF12 control of MOV10 during spermatogenesis in human cells. The layout distinguishes each component clearly with labels and symbols that align with the description provided. The positioning of elements inside a spermatocyte emphasizes the cellular context, while the use of arrows and symbols indicates the direction and nature of regulation and interaction. The color coding and symbols enhance understanding, with a legend providing clear definitions. Overall, the visual communication of complex interactions is done well, maintaining clarity and simplicity in depicting the ubiquitin-dependent pathway and its relevant components.","necessary_changes":null,"optional_changes":null}