Figure: Negative regulation of glycolytic process through fructose-6-phosphate 2 (Mouse)¶
This figure illustrates the negative regulation of glycolytic process through fructose-6-phosphate 2 in mouse liver cells. The pathway shows how protein kinase A (Prkaca) inhibits phosphofructokinase-2/fructose-2,6-bisphosphatase (Pfkfb1), leading to reduced levels of fructose-2,6-bisphosphate (F-2,6-BP). This reduction decreases the activation of phosphofructokinase (Pfkl), a key enzyme in glycolysis, ultimately resulting in negative regulation of the glycolytic process. The pathway also shows the role of glucose-6-phosphate isomerase (Gpi1) in converting glucose-6-phosphate (G-6-P) to fructose-6-phosphate (F-6-P). Protein components are represented by distinct shapes and colors: rectangles for kinases and regulatory enzymes, circles for isomerases, and ovals for metabolites. Arrow types indicate different relationships: dashed red arrows for inhibition, solid green arrows for activation, and black arrows for metabolic conversions.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the negative regulation of glycolytic process in mouse liver cells. The visual representation clearly shows the key proteins and their interactions in the pathway. The use of consistent color coding, appropriate shapes, and directional arrows makes the diagram easy to follow and understand. The numbered steps with explanatory notes enhance clarity, and the inclusion of a legend and pathway summary provides additional context for interpretation. The diagram captures the essential elements of the GO-CAM model while presenting them in a visually appealing and scientifically accurate manner suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}