Figure: TRIM22-NT5C2 regulation of RIGI via ubiquitination (Human)¶
This diagram illustrates the TRIM22-NT5C2 regulation of RIGI via ubiquitination in human cells. The pathway involves two contrasting ubiquitination events: NT5C2 performs K48-linked ubiquitination on RIGI (inhibitory), while TRIM22 performs K63-linked ubiquitination on RIGI (activatory). Upon activation, RIGI stimulates MAVS at the mitochondrial membrane, playing a key role in the antiviral innate immune response (GO:0140374).
The colors represent different proteins and their functions: - Blue (NT5C2): E3 ubiquitin ligase that inhibits RIGI through K48-linked ubiquitination - Pink (TRIM22): E3 ubiquitin ligase that activates RIGI through K63-linked ubiquitination - Green (RIGI): Pattern recognition receptor that senses viral RNA - Yellow (MAVS): Signaling adaptor at the mitochondrial membrane
Red arrows indicate inhibitory relationships, while green arrows indicate activating relationships.
All components are found in the cytoplasm (GO:0005737), except for MAVS which localizes to the mitochondrial membrane (GO:0031966).
Feedback from AI on figure:
{"feedback":"The diagram clearly and effectively portrays the TRIM22-NT5C2 regulation of RIGI via ubiquitination, following a style appropriate for publication in journals like Cell or Nature. The key strengths of this illustration include:\n\n1. Clear visual organization that accurately represents the subcellular localization of each component (cytoplasm vs. mitochondrial membrane)\n\n2. Distinct visual encoding using appropriate shapes and colors to differentiate protein types and their functions\n\n3. Well-labeled arrows showing the direction and nature of interactions (inhibitory K48-linked ubiquitination vs. activatory K63-linked ubiquitination)\n\n4. Bold, legible text with consistent formatting and appropriate emphasis on key terms\n\n5. Comprehensive legend that provides context and explains the molecular functions and GO terms\n\nThe diagram faithfully represents the GO-CAM data while using artistic styling that would be appropriate for a high-impact journal publication. The enlarged text size in the final version improves readability while maintaining the clean, professional aesthetic.","necessary_changes":null,"optional_changes":null}