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Figure: DHX16-mediated viral RNA recognition and activation of RIGI (Human)

id: gomodel:63a86a8600001202

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The figure depicts DHX16-mediated viral RNA recognition and activation of RIG-I in human cells, a key pathway in antiviral innate immune response. The pathway follows 5 sequential steps:

  1. DHX16 (blue) recognizes viral RNA (red) in the cytoplasm through pattern recognition receptor activity (GO:0038187).

  2. TRIM6 (orange) functions as a ubiquitin protein ligase (GO:0061630) to generate free polyubiquitin chains (yellow) through polymerization (GO:0010994).

  3. DHX16 binds to these polyubiquitin chains through its ubiquitin binding activity (GO:0043130).

  4. DHX16 acts as a molecular adaptor (GO:0060090) to interact with RIG-I (dark blue).

  5. This interaction leads to the activation of RIG-I (indicated by red outline), which then exerts its pattern recognition receptor activity (GO:0038187).

All these activities occur in the cytoplasm (GO:0005737) and collectively contribute to the antiviral innate immune response (GO:0140374). Proteins are labeled with their UniProtKB identifiers (DHX16: O60231, TRIM6: Q9C030, RIG-I: O95786).

Feedback from AI on figure:

{"feedback":"The illustration effectively captures the DHX16-mediated viral RNA recognition pathway in a clear and scientifically accurate manner. The sequential numbering system (steps 1-5) helps guide the viewer through the process, while the use of distinctive colors for different proteins (DHX16, TRIM6, RIG-I) enhances visual clarity. The incorporation of GO terms and UniProtKB identifiers provides valuable reference information for researchers. The pathway demonstrates the molecular interactions leading to RIG-I activation, with appropriate representation of the cytoplasmic environment. The overall design balances scientific precision with visual accessibility, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}