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Figure: Triglyceride biosynthetic process 1 (Mouse)

id: gomodel:63a86a8600001386

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This diagram illustrates the triglyceride biosynthetic pathway in mouse cells, highlighting the key enzymes involved in sequential steps of the process. The pathway spans multiple cellular compartments:

  1. The process begins with Agmo (glyceryl-ether monooxygenase) in the endoplasmic reticulum membrane.
  2. Gk (glycerol kinase) in the cytosol generates glycerol-3-phosphate.
  3. Gpam (glycerol-3-phosphate O-acyltransferase) in the mitochondrial outer membrane transfers acyl groups.
  4. Agpat2 (1-acylglycerol-3-phosphate O-acyltransferase) in the ER membrane catalyzes the formation of phosphatidic acid (PA).
  5. Lpin2 (phosphatidate phosphatase) in the ER membrane converts PA to diacylglycerol (DAG).
  6. Finally, Dgat2 (diacylglycerol O-acyltransferase) in the ER membrane produces the final product, triacylglycerol/triglyceride (TAG).

Each enzyme is color-coded, and the pathway flows from left to right along the ER membrane with contributions from the cytosol and mitochondria. This representation follows the Gene Ontology Causal Activity Model (GO-CAM) for triglyceride biosynthesis in mouse cells.

Feedback from AI on figure:

{"feedback":"The SVG drawing effectively communicates the triglyceride biosynthetic pathway in mouse cells with high clarity and scientific accuracy. The illustration successfully captures clear differentiation between cellular compartments using color and pattern, precise placement of enzymes in their appropriate cellular locations, well-positioned labels that avoid overlap with other elements, and a logical flow of the pathway with directional arrows. The comprehensive legend identifies all gene products, and the abbreviations section helpfully explains metabolic intermediates. The drawing style is appropriate for publication in high-impact journals like Cell or Nature, featuring a clean, professional aesthetic with balanced visual elements and consistent typography.","necessary_changes":null,"optional_changes":null}