Figure: The AIM2 inflammasome (Mouse)¶
This diagram illustrates the AIM2 inflammasome pathway in mouse cells. The pathway begins when cytosolic double-stranded DNA (dsDNA) is bound by AIM2 (Aim2) in the cytoplasm. This binding activates AIM2's pattern recognition receptor (PRR) activity, leading to the recruitment of ASC/PYCARD (not explicitly in the GO-CAM source but included for pathway completeness).
The AIM2-ASC interaction facilitates the assembly of the AIM2 inflammasome complex, which recruits pro-caspase-1 (Pro-Casp1). Within this complex, AIM2 functions as a signaling adaptor that activates caspase-1 through its cysteine-type endopeptidase activator activity. Activated caspase-1 (Casp1) then cleaves pro-gasdermin D (Pro-GSDMD) through its cysteine-type endopeptidase activity.
This cleavage releases the N-terminal fragment of gasdermin D (GSDMD-N), which translocates to the plasma membrane where it binds phosphatidylinositol-4,5-bisphosphate (PIP2). This binding enables GSDMD-N to form pores in the plasma membrane through its wide pore channel activity, ultimately resulting in pyroptotic inflammatory response.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the AIM2 inflammasome pathway, clearly showing the progression from cytosolic DNA detection to pyroptotic inflammatory response. The color-coded pathway elements and directional arrows make the sequence of events easy to follow. The compartmentalization between cytoplasm and plasma membrane is clearly defined, and all key molecular interactions are appropriately represented.","necessary_changes":null,"optional_changes":"The color-coding of arrows to match the proteins helps differentiate the various steps of the pathway. The improved visibility of the inflammatory response label enhances clarity. The diagram successfully represents all components of the GO-CAM model while organizing them in a visually appealing manner suitable for publication."}