Figure: FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human)

id: gomodel:63c0ac2b00001613

The diagram illustrates the FBXO9-mediated degradation of CARM1 leading to epithelial cell survival in humans.

The SCF ubiquitin ligase complex (composed of SKP1, CUL1, RBX1, and FBXO9) targets CARM1 for K48-linked ubiquitination, marking it for proteasomal degradation. CARM1 is a protein methyltransferase that normally promotes epithelial cell apoptosis by activating caspase-3 (CASP3).

By facilitating CARM1 degradation, FBXO9 inhibits the pathway leading to apoptosis, thereby promoting epithelial cell survival. The ubiquitin ligase activity of RBX1, the scaffold activity of SKP1 and CUL1, and the substrate adaptor activity of FBXO9 are all critical for this regulatory mechanism.

The T-bar connections indicate inhibitory relationships in the pathway, while arrows show promoting activities.

Feedback from AI on figure:

{"feedback":"The diagram effectively captures the FBXO9-mediated degradation of CARM1 pathway leading to epithelial cell survival. The use of clear shapes, distinct colors, and appropriate labels makes the biological process easy to follow. The inhibitory relationships are well-represented using T-bar connections, and the promoting relationships use directional arrows. The legend provides comprehensive information about all elements in the diagram, making it suitable for publication in a scientific journal like Cell or Nature.","necessary_changes":null,"optional_changes":"The revised version includes enlarged labels for better readability and an enhanced legend with additional details about protein functions. The color scheme effectively differentiates between different components of the pathway, and the layout provides a clear visual narrative of how FBXO9-mediated degradation of CARM1 prevents apoptosis and promotes cell survival."}